{"id":515,"date":"2026-08-09T23:58:41","date_gmt":"2026-08-09T21:58:41","guid":{"rendered":"http:\/\/longevitygoods.local\/product\/b-supreme-designs-for-health\/"},"modified":"2026-09-03T00:16:12","modified_gmt":"2026-09-02T22:16:12","slug":"designs-health-b-supreme-bioactive-b-complex-5-mthf-folate","status":"publish","type":"product","link":"https:\/\/longevitygoods.com\/nl\/product\/designs-health-b-supreme-bioactive-b-complex-5-mthf-folate\/","title":{"rendered":"Designs for Health B-Supreme \u2013 Bioactief B-complex met 5-MTHF-folaat & Methyl-B12 (120 Capsules)"},"content":{"rendered":"
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Complete B-vitamin complex from Designs for Health<\/p>\n

B-Supreme contains the whole B-vitamin family in bioactive, methylated forms \u2013 including methylfolate (Quatrefolic\u00ae) and methylcobalamin \u2013 plus extra support from choline and trimethylglycine (TMG) for methylation processes.<\/p>\n<\/div>\n

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Active B vitamins<\/div>\n
8vitamins<\/span><\/div>\n
B1, B2, B3, B6, folate, B12, biotin, B5<\/div>\n<\/div>\n
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Methylation support<\/div>\n
+2cofactors<\/span><\/div>\n
choline & TMG (betaine)<\/div>\n<\/div>\n
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Size<\/div>\n
120capsules<\/span><\/div>\n
vegetarian capsules<\/div>\n<\/div>\n
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Dosage<\/div>\n
1capsule\/day<\/span><\/div>\n
lasts 4 months<\/div>\n<\/div>\n<\/div>\n
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About bioactive B vitamins<\/h2>\n

B vitamins act as cofactors in thousands of enzymatic processes, including energy metabolism, methylation, the synthesis of neurotransmitters and maintenance of the nervous system. Many ordinary supplements use synthetic, cheap forms (such as folic acid and cyanocobalamin) that the body has to convert into the active form before it can use them. B-Supreme instead uses bioactive, methylated forms directly \u2013 for example methylfolate (Quatrefolic\u00ae) instead of folic acid, and methylcobalamin instead of cyanocobalamin.<\/p>\n

\nRead more<\/span>Show less<\/span><\/summary>\n
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The formula contains folate as 5-MTHF and B12 as methylcobalamin, that is, already bioactive forms. This is described in journals such as Journal of Inherited Metabolic Disease<\/em>: some people find it harder to convert folic acid into methylfolate. In longevity protocols, methylation has become a commonly used concept, and bioactive B-vitamin forms are one of the most sought-after supplement categories.<\/p>\n

B-Supreme goes a step further by including choline (30 mg) and trimethylglycine \/ TMG (200 mg) as methyl donors. Choline and TMG (betaine) are both in the formula alongside the eight B vitamins. On social media, B-Supreme is sometimes called “the methylation stack in a capsule” \u2013 an expression of how closely the formula is aimed at biohackers and longevity-focused users.<\/p>\n<\/div>\n<\/details>\n<\/div>\n

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Contents per capsule<\/h2>\n\n\n\n\n\n\n\n
Ingredient<\/th>\nAmount<\/th>\n<\/tr>\n<\/thead>\n
Trimethylglycine (TMG \/ betaine)<\/td>\n200 mg<\/td>\n<\/tr>\n
Thiamine (vitamin B1 as thiamine HCl)<\/td>\n100 mg<\/td>\n<\/tr>\n
Pantothenic acid (vitamin B5 as d-calcium pantothenate)<\/td>\n100 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\nShow all 10 ingredients<\/span>Show fewer<\/span><\/summary>\n\n\n\n\n\n\n\n\n\n
Riboflavin (vitamin B2 + riboflavin-5-phosphate)<\/td>\n50 mg<\/td>\n<\/tr>\n
Niacin (vitamin B3 as niacinamide)<\/td>\n50 mg NE<\/td>\n<\/tr>\n
Vitamin B6 (pyridoxine HCl + pyridoxal-5-phosphate)<\/td>\n50 mg<\/td>\n<\/tr>\n
Choline (choline bitartrate)<\/td>\n30 mg<\/td>\n<\/tr>\n
Biotin (d-biotin)<\/td>\n2,000 mcg<\/td>\n<\/tr>\n
Folate (Quatrefolic\u00ae \/ 6S-5-methyltetrahydrofolate)<\/td>\n340 mcg DFE<\/td>\n<\/tr>\n
Vitamin B12 (methylcobalamin)<\/td>\n250 mcg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/details>\n

Other ingredients:<\/strong> cellulose (capsule), stearates (of vegetable origin), silicon dioxide.<\/p>\n<\/div>\n

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Use<\/h2>\n
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Recommended dose: 1 capsule daily with a meal.<\/p>\n

Or as directed by a doctor or other healthcare professional. Store in a dry, cool place. B vitamins can turn urine yellow \u2013 this is entirely normal and harmless.<\/p>\n<\/div>\n<\/div>\n

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Quality and certifications<\/h2>\n
\n\u2713<\/span>Gluten-free<\/span>
\n\u2713<\/span>Dairy-free<\/span>
\n\u2713<\/span>Soy-free<\/span>
\n\u2713<\/span>Vegetarian<\/span>
\n\u2713<\/span>Vegan<\/span>
\n\u2713<\/span>Non-GMO<\/span>
\n\u2713<\/span>cGMP certified<\/span>\n<\/div>\n<\/div>\n
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Learn more<\/h2>\n
\nWho is B-Supreme for?<\/summary>\n

B-Supreme is popular among people following an active longevity protocol and biohackers, and among those who prefer a single B-vitamin complex in bioactive form over individual B vitamins. It is also popular among vegetarians and vegans, who often need support with B12 and choline.<\/p>\n<\/details>\n

\nWhat is methylation and why does it matter?<\/summary>\n

Methylation is a biochemical process in which a methyl group (-CH3) is moved between molecules. It happens thousands of times per second in the body and affects the folate cycle, methionine metabolism and the body’s own methylation reactions among other things. B vitamins (particularly folate, B12 and B6) together with choline and TMG are central methyl donors. The product is not a replacement for medical treatment.<\/p>\n<\/details>\n

\nWhen during the day should I take B-Supreme?<\/summary>\n

B-Supreme is taken with a meal, ideally in the morning or at lunch since the B vitamins can be mildly activating. Avoid taking it late in the evening if you are sensitive to energising effects.<\/p>\n<\/details>\n

\nHow long does one jar last?<\/summary>\n

One jar contains 120 capsules. At the recommended dose of 1 capsule daily it lasts 120 days, that is about 4 months.<\/p>\n<\/details>\n

\nIs B-Supreme vegan?<\/summary>\n

Yes. B-Supreme is gluten-free, dairy-free, soy-free, vegetarian, vegan and non-GMO. All the B vitamins are made synthetically or by yeast fermentation and the capsule is plant-based cellulose.<\/p>\n<\/details>\n

\nWhy do B vitamins turn my urine yellow?<\/summary>\n

The yellow colour comes from riboflavin (vitamin B2), which is excreted in the urine. It is entirely harmless and simply means the body is excreting the surplus it did not need. B vitamins are water-soluble and cannot be stored in the body to the same extent as fat-soluble vitamins.<\/p>\n<\/details>\n

\nWhere and how is B-Supreme made?<\/summary>\n

B-Supreme is made in the USA by Designs for Health in a facility following cGMP standards (current Good Manufacturing Practices) regulated by the FDA. The raw materials undergo third-party testing for identity and potency, and the Quatrefolic\u00ae form of folate is a patented ingredient from the Italian company Gnosis.<\/p>\n<\/details>\n<\/div>\n

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About Designs for Health<\/h2>\n

Designs for Health is an American supplement brand founded in 1989 with a focus on functional medicine practitioners. The company has positioned itself as the “Science First” brand and has for several years been ranked the most recommended supplement brand among functional medicine practitioners in the USA.<\/p>\n

\nRead more<\/span>Show less<\/span><\/summary>\n
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Manufacturing takes place in the USA to cGMP standards, with third-party testing of raw materials and finished products. Designs for Health works with clinicians and researchers to develop formulas based on published literature. The philosophy is to combine ingredients in synergistic blends with a focus on bioactive forms \u2013 B-Supreme is a good example of how they add methyl donors such as choline and TMG to strengthen the formula beyond the individual B vitamins.<\/p>\n<\/div>\n<\/details>\n<\/div>\n

\nTap here for important information about food supplements<\/summary>\n
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Food supplements are not intended to replace a varied diet or medical treatment. Do not exceed the recommended daily dose. Keep out of reach of young children. Consult a doctor if you are pregnant, breastfeeding, unwell or taking medication.<\/p>\n<\/div>\n<\/details>\n

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Pairs well with<\/h2>\n
\"Designs<\/span>Bone Broth Protein<\/span>collagen protein from grass-fed swedish cattle<\/span><\/a>\"Designs<\/span>Complete Mineral Complex<\/span>iron-free mineral complex with chelated<\/span><\/a>\"Designs<\/span>CoQnol 100<\/span>active ubiquinol coq10 with geranylgeraniol<\/span><\/a>\"Blueprint<\/span>Blueprint Creatine<\/span>5 g creatine monohydrate per serving<\/span><\/a><\/div>\n

You can read more about food supplements and what is worth keeping in mind at the European Food Safety Authority<\/a>.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

B-Supreme van Designs for Health \u2013 een B-vitaminecomplex in bioactieve vorm met methylfolaat (Quatrefolic\u00ae), methylcobalamine (B12), TMG en choline. 120 vegan capsules.<\/p>\n","protected":false},"featured_media":516,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[32],"product_cat":[140,151],"product_tag":[],"product_need":[128],"class_list":["post-515","product","type-product","status-publish","has-post-thumbnail","product_brand-designs-for-health","product_cat-supplements","product_cat-vitamins","product_need-energy-focus","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/product\/515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/comments?post=515"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/media\/516"}],"wp:attachment":[{"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/media?parent=515"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/product_brand?post=515"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/product_cat?post=515"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/product_tag?post=515"},{"taxonomy":"product_need","embeddable":true,"href":"https:\/\/longevitygoods.com\/nl\/wp-json\/wp\/v2\/product_need?post=515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}