{"id":494,"date":"2026-08-09T23:58:10","date_gmt":"2026-08-09T21:58:10","guid":{"rendered":"http:\/\/longevitygoods.local\/product\/homocysteine-supreme-designs-for-health\/"},"modified":"2026-09-03T00:16:11","modified_gmt":"2026-09-02T22:16:11","slug":"designs-health-homocysteine-supreme-tmg-5-mthf-folate-methyl","status":"publish","type":"product","link":"https:\/\/longevitygoods.com\/pl\/product\/designs-health-homocysteine-supreme-tmg-5-mthf-folate-methyl\/","title":{"rendered":"Designs for Health Homocysteine Supreme\u2122 \u2013 TMG, folian 5-MTHF & metylo-B12 (60 kapsu\u0142ek)"},"content":{"rendered":"
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Methylation and B-vitamin formula from Designs for Health<\/p>\n

Homocysteine Supreme\u2122 is a powerful methylation formula with active B vitamins (R-5-P, P-5-P, Quatrefolic\u00ae folate, methylcobalamin) plus 900 mg of TMG and L-serine. A B-vitamin complex with TMG, 5-MTHF folate, methylcobalamin, B2 and B6.<\/p>\n<\/div>\n

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Active ingredients<\/div>\n
6pcs<\/span><\/div>\n
B vitamins + methyl donors<\/div>\n<\/div>\n
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TMG (trimethylglycine)<\/div>\n
900mg<\/span><\/div>\n
betaine for methylation<\/div>\n<\/div>\n
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Size<\/div>\n
60capsules<\/span><\/div>\n
vegetarian capsules<\/div>\n<\/div>\n
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Dosage<\/div>\n
2capsules\/day<\/span><\/div>\n
lasts 30 days<\/div>\n<\/div>\n<\/div>\n
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About homocysteine and methylation<\/h2>\n

Homocysteine is an amino acid formed when methionine is metabolised in the body’s methylation process. Homocysteine is an amino acid the body forms when methionine is metabolised. The B vitamins B2 (riboflavin), B6, folate and B12 all take part in the methylation and transsulphuration pathways, the processes in which homocysteine is metabolised. Homocysteine Supreme\u2122 uses the active, bioavailable forms of all of them.<\/p>\n

\nRead more<\/span>Show less<\/span><\/summary>\n
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People with a genetic variation in the MTHFR gene (the C677T and A1298C polymorphisms are the most common) often find it harder to convert folic acid into the active form [6S]-5-methyltetrahydrofolate. Quatrefolic\u00ae is a patented source of exactly this active folate form and has been studied for better bioavailability even in people with MTHFR variants. In the same way, Homocysteine Supreme\u2122 delivers methyl-B12 (methylcobalamin), pyridoxal-5-phosphate (P-5-P) and riboflavin-5-phosphate (R-5-P) \u2013 the active coenzyme forms.<\/p>\n

Trimethylglycine (TMG, also called betaine) is a methyl donor that supports methylation alongside the B vitamins. L-serine is an amino acid needed in the transsulphuration pathway of homocysteine metabolism. In functional medicine this type of formula is often used as support for people with raised homocysteine, MTHFR variants, or simply as methylation support for adults and seniors.<\/p>\n<\/div>\n<\/details>\n<\/div>\n

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Contents per 2 capsules (daily dose)<\/h2>\n\n\n\n\n\n\n\n
Ingredient<\/th>\nAmount<\/th>\n<\/tr>\n<\/thead>\n
Folate (Quatrefolic\u00ae [6S]-5-methyltetrahydrofolate, glucosamine salt)<\/td>\n3,400 mcg DFE<\/td>\n<\/tr>\n
Vitamin B12 (methylcobalamin)<\/td>\n1,000 mcg<\/td>\n<\/tr>\n
Trimethylglycine (TMG, betaine)<\/td>\n900 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\nShow all ingredients<\/span>Show fewer<\/span><\/summary>\n\n\n\n\n\n
Riboflavin (B2 as riboflavin-5-phosphate)<\/td>\n30 mg<\/td>\n<\/tr>\n
Vitamin B6 (pyridoxal-5-phosphate)<\/td>\n10 mg<\/td>\n<\/tr>\n
L-serine<\/td>\n100 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/details>\n

Other ingredients:<\/strong> cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, dicalcium phosphate, silicon dioxide.<\/p>\n<\/div>\n

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Use<\/h2>\n
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Recommended dose: 2 capsules daily with a meal.<\/p>\n

Or as directed by a doctor or other healthcare professional. Store in a dry, cool place.<\/p>\n<\/div>\n<\/div>\n

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Quality and certifications<\/h2>\n
\n\u2713<\/span>Gluten-free<\/span>
\n\u2713<\/span>Dairy-free<\/span>
\n\u2713<\/span>Soy-free<\/span>
\n\u2713<\/span>Vegetarian<\/span>
\n\u2713<\/span>Vegan<\/span>
\n\u2713<\/span>Non-GMO<\/span>
\n\u2713<\/span>Active B vitamins<\/span>
\n\u2713<\/span>cGMP certified<\/span>\n<\/div>\n<\/div>\n
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Learn more<\/h2>\n
\nWho is Homocysteine Supreme\u2122 for?<\/summary>\n

Homocysteine Supreme\u2122 suits adults who want a concentrated B-vitamin complex with TMG in bioactive forms. It is popular among biohackers and the longevity-focused who want bioactive B-vitamin forms in a single formula.<\/p>\n<\/details>\n

\nWhat is MTHFR and why does it matter?<\/summary>\n

MTHFR is an enzyme that converts folic acid into its active form (5-MTHF). People with certain genetic variants (such as C677T) may be less able to make this conversion and therefore benefit from supplements containing already-active folate \u2013 which is what Quatrefolic\u00ae delivers. The product is not a replacement for medical treatment. If a test shows raised homocysteine, you should consult a doctor.<\/p>\n<\/details>\n

\nWhat is the difference between ordinary folic acid and Quatrefolic\u00ae?<\/summary>\n

Folic acid is the synthetic form that has to be converted into active folate in the body over several steps. Quatrefolic\u00ae is already in the active, bioavailable form [6S]-5-MTHF and needs no conversion, which makes it particularly suitable for people with MTHFR variants or others who want to maximise absorption.<\/p>\n<\/details>\n

\nWhen during the day should I take the product?<\/summary>\n

Homocysteine Supreme\u2122 is best taken with breakfast or lunch, since B vitamins can be somewhat energising. Many people avoid taking them in the evening.<\/p>\n<\/details>\n

\nHow long does one jar last?<\/summary>\n

One jar contains 60 capsules. At the recommended dose of 2 capsules daily it lasts 30 days, that is about 1 month.<\/p>\n<\/details>\n

\nWhere and how is Homocysteine Supreme\u2122 made?<\/summary>\n

The product is made in the USA by Designs for Health in a facility following cGMP standards regulated by the FDA. The raw materials Quatrefolic\u00ae, methylcobalamin and TMG undergo third-party testing for identity, potency and the absence of heavy metals.<\/p>\n<\/details>\n

\nCan I combine it with other B vitamins?<\/summary>\n

Homocysteine Supreme\u2122 is a high-strength methylation formula and normally does not need to be combined with a separate B complex. If you already take B-Supreme or similar, do consult a nutritional therapist to avoid overlap.<\/p>\n<\/details>\n<\/div>\n

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About Designs for Health<\/h2>\n

Designs for Health is an American supplement brand founded in 1989 with a focus on functional medicine practitioners. The company has positioned itself as the „Science First” brand and has for several years been ranked the most recommended supplement brand among functional medicine practitioners in the USA.<\/p>\n

\nRead more<\/span>Show less<\/span><\/summary>\n
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Homocysteine Supreme\u2122 is a classic example of Designs for Health’s philosophy of choosing bioactive, scientifically well-supported forms (Quatrefolic\u00ae folate, methylcobalamin, P-5-P) instead of cheaper synthetic versions (folic acid, cyanocobalamin, pyridoxine HCl). This is one of the company’s most popular products in the methylation support category.<\/p>\n<\/div>\n<\/details>\n<\/div>\n

\nTap here for important information about food supplements<\/summary>\n
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Food supplements are not intended to replace a varied diet or medical treatment. Do not exceed the recommended daily dose. Keep out of reach of young children. Consult a doctor if you are pregnant, breastfeeding, unwell or taking medication.<\/p>\n<\/div>\n<\/details>\n<\/div>\n

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Substance<\/h2>\n

Substance:<\/strong> Active folate (Quatrefolic\u00ae) 3,400 \u00b5g DFE, B12 (methylcobalamin) 1,000 \u00b5g and trimethylglycine (TMG) 900 mg per daily dose (2 capsules), plus riboflavin (R-5-P) 30 mg, B6 (P-5-P) 10 mg and L-serine 100 mg.<\/p>\n<\/div>\n

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Pairs well with<\/h2>\n
\"Designs<\/span>IgGI Shield<\/span>a dairy-free formula with immunoglobulin & n-acetyl-d-glucosamine<\/span><\/a>\"Designs<\/span>Inflammatone<\/span>a botanical formula with turmeric & boswellia<\/span><\/a>\"Designs<\/span>N-Acetyl-L-Cysteine (NAC) 900 mg<\/span>900 mg per capsule<\/span><\/a>\"Blueprint<\/span>Blueprint Creatine<\/span>5 g creatine monohydrate per serving<\/span><\/a><\/div>\n

You can read more about food supplements and what is worth keeping in mind at the European Food Safety Authority<\/a>.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Homocysteine Supreme\u2122 od Designs for Health \u2013 kompleks witamin B w formie bioaktywnej z TMG (betain\u0105), folianem 5-MTHF, metylokobalamin\u0105 (B12), ryboflawin\u0105 (B2) i B6. 60 wega\u0144skich kapsu\u0142ek.<\/p>\n","protected":false},"featured_media":495,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[32],"product_cat":[140,151],"product_tag":[],"product_need":[131],"class_list":["post-494","product","type-product","status-publish","has-post-thumbnail","product_brand-designs-for-health","product_cat-supplements","product_cat-vitamins","product_need-heart-health","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/product\/494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/comments?post=494"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/media\/495"}],"wp:attachment":[{"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/media?parent=494"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/product_brand?post=494"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/product_cat?post=494"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/product_tag?post=494"},{"taxonomy":"product_need","embeddable":true,"href":"https:\/\/longevitygoods.com\/pl\/wp-json\/wp\/v2\/product_need?post=494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}