Designs for Health Homocysteine Supreme™ – TMG, 5-MTHF Folate & Methyl-B12 (60 Capsules)
€ 55,95
Homocysteine Supreme™ from Designs for Health – a B-vitamin complex in bioactive form with TMG (betaine), 5-MTHF folate, methylcobalamin (B12), riboflavin (B2) and B6. 60 vegan capsules.
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- Shipped from within the EU
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Ingredients
Folate (Quatrefolic® [6S]-5-methyltetrahydrofolate, glucosamine salt), Vitamin B12 (methylcobalamin), Trimethylglycine (TMG, betaine), Riboflavin (B2 as riboflavin-5-phosphate), Vitamin B6 (pyridoxal-5-phosphate), L-serine. Other ingredients: cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, dicalcium phosphate, silicon dioxide.
Full list with amountsHow to Use
Recommended dose: 2 capsules daily with a meal.
Full instructionsThird-party testing
Designs for Health publishes the laboratory report for this product. It opens on their own site — we link the original rather than keeping a copy that would go stale.
How we check third-party testingShipping and Returns
Orders over € 169 ship free within the EU. Below that, shipping is € 14,95 anywhere in the EU (€ 9,95 within Sweden), added at checkout. Unopened items can be returned within 30 days of arrival.
Product Details
Methylation and B-vitamin formula from Designs for Health
Homocysteine Supreme™ is a powerful methylation formula with active B vitamins (R-5-P, P-5-P, Quatrefolic® folate, methylcobalamin) plus 900 mg of TMG and L-serine. A B-vitamin complex with TMG, 5-MTHF folate, methylcobalamin, B2 and B6.
About homocysteine and methylation
Homocysteine is an amino acid formed when methionine is metabolised in the body’s methylation process. Homocysteine is an amino acid the body forms when methionine is metabolised. The B vitamins B2 (riboflavin), B6, folate and B12 all take part in the methylation and transsulphuration pathways, the processes in which homocysteine is metabolised. Homocysteine Supreme™ uses the active, bioavailable forms of all of them.
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People with a genetic variation in the MTHFR gene (the C677T and A1298C polymorphisms are the most common) often find it harder to convert folic acid into the active form [6S]-5-methyltetrahydrofolate. Quatrefolic® is a patented source of exactly this active folate form and has been studied for better bioavailability even in people with MTHFR variants. In the same way, Homocysteine Supreme™ delivers methyl-B12 (methylcobalamin), pyridoxal-5-phosphate (P-5-P) and riboflavin-5-phosphate (R-5-P) – the active coenzyme forms.
Trimethylglycine (TMG, also called betaine) is a methyl donor that supports methylation alongside the B vitamins. L-serine is an amino acid needed in the transsulphuration pathway of homocysteine metabolism. In functional medicine this type of formula is often used as support for people with raised homocysteine, MTHFR variants, or simply as methylation support for adults and seniors.
Contents per 2 capsules (daily dose)
| Ingredient | Amount |
|---|---|
| Folate (Quatrefolic® [6S]-5-methyltetrahydrofolate, glucosamine salt) | 3,400 mcg DFE |
| Vitamin B12 (methylcobalamin) | 1,000 mcg |
| Trimethylglycine (TMG, betaine) | 900 mg |
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| Riboflavin (B2 as riboflavin-5-phosphate) | 30 mg |
| Vitamin B6 (pyridoxal-5-phosphate) | 10 mg |
| L-serine | 100 mg |
Other ingredients: cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, dicalcium phosphate, silicon dioxide.
Use
Recommended dose: 2 capsules daily with a meal.
Or as directed by a doctor or other healthcare professional. Store in a dry, cool place.
Quality and certifications
✓Dairy-free
✓Soy-free
✓Vegetarian
✓Vegan
✓Non-GMO
✓Active B vitamins
✓cGMP certified
Learn more
Who is Homocysteine Supreme™ for?
Homocysteine Supreme™ suits adults who want a concentrated B-vitamin complex with TMG in bioactive forms. It is popular among biohackers and the longevity-focused who want bioactive B-vitamin forms in a single formula.
What is MTHFR and why does it matter?
MTHFR is an enzyme that converts folic acid into its active form (5-MTHF). People with certain genetic variants (such as C677T) may be less able to make this conversion and therefore benefit from supplements containing already-active folate – which is what Quatrefolic® delivers. The product is not a replacement for medical treatment. If a test shows raised homocysteine, you should consult a doctor.
What is the difference between ordinary folic acid and Quatrefolic®?
Folic acid is the synthetic form that has to be converted into active folate in the body over several steps. Quatrefolic® is already in the active, bioavailable form [6S]-5-MTHF and needs no conversion, which makes it particularly suitable for people with MTHFR variants or others who want to maximise absorption.
When during the day should I take the product?
Homocysteine Supreme™ is best taken with breakfast or lunch, since B vitamins can be somewhat energising. Many people avoid taking them in the evening.
How long does one jar last?
One jar contains 60 capsules. At the recommended dose of 2 capsules daily it lasts 30 days, that is about 1 month.
Where and how is Homocysteine Supreme™ made?
The product is made in the USA by Designs for Health in a facility following cGMP standards regulated by the FDA. The raw materials Quatrefolic®, methylcobalamin and TMG undergo third-party testing for identity, potency and the absence of heavy metals.
Can I combine it with other B vitamins?
Homocysteine Supreme™ is a high-strength methylation formula and normally does not need to be combined with a separate B complex. If you already take B-Supreme or similar, do consult a nutritional therapist to avoid overlap.
About Designs for Health
Designs for Health is an American supplement brand founded in 1989 with a focus on functional medicine practitioners. The company has positioned itself as the “Science First” brand and has for several years been ranked the most recommended supplement brand among functional medicine practitioners in the USA.
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Homocysteine Supreme™ is a classic example of Designs for Health’s philosophy of choosing bioactive, scientifically well-supported forms (Quatrefolic® folate, methylcobalamin, P-5-P) instead of cheaper synthetic versions (folic acid, cyanocobalamin, pyridoxine HCl). This is one of the company’s most popular products in the methylation support category.
Tap here for important information about food supplements
Food supplements are not intended to replace a varied diet or medical treatment. Do not exceed the recommended daily dose. Keep out of reach of young children. Consult a doctor if you are pregnant, breastfeeding, unwell or taking medication.
Substance
Substance: Active folate (Quatrefolic®) 3,400 µg DFE, B12 (methylcobalamin) 1,000 µg and trimethylglycine (TMG) 900 mg per daily dose (2 capsules), plus riboflavin (R-5-P) 30 mg, B6 (P-5-P) 10 mg and L-serine 100 mg.
Pairs well with
IgGI Shielda dairy-free formula with immunoglobulin & n-acetyl-d-glucosamine
Inflammatonea botanical formula with turmeric & boswellia
N-Acetyl-L-Cysteine (NAC) 900 mg900 mg per capsule
Blueprint Creatine5 g creatine monohydrate per servingYou can read more about food supplements and what is worth keeping in mind at the European Food Safety Authority.
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